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Sylentis Aims to Begin Phase I Study of Glaucoma Drug in September

Submitted by dave on Sun, 08/30/2009 - 12:20pm

By Doug Macron

Spanish RNAi drug shop Sylentis expects to dose the first patient in a phase I study of its glaucoma-associated ocular hypertension drug SYL040012 in Spain around the end of September, a company official confirmed to RNAi News this week.

The disclosure comes about a month after the company announced that it had received clearance from Spanish regulators to begin the trial, in line with its previously disclosed guidance (see RNAi News, 2/19/2009).

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Gingko Biloba shown to protect optic nerve cells from injury

Submitted by dave on Thu, 08/27/2009 - 10:05am

Oral consumption of Ginkgo biloba led to a higher survival rate of optic nerve cells (retinal ganglion cells). The effect was dosage-dependent - the higher concentrations of Ginkgo resulted in higher optic nerve cell survival rates. The dosages of Ginkgo were comparable to those an average person could safely consume.

Dosage dependence of the effect of Ginkgo biloba on the rat retinal ganglion cell survival after optic nerve crush - Abstract 

Relationship of Incident Glaucoma versus Physical Activity and Fitness in Male Runners

Submitted by dave on Mon, 08/17/2009 - 1:47pm

runningPurpose: To assess the dose-response relationship of vigorous physical activity (running distance, km·d-1) or cardiorespiratory fitness (meters-per-second pace during a 10-km footrace) to the risk for incident glaucoma.

Conclusions: These data provide preliminary evidence that vigorous physical activity may reduce glaucoma risk, which, in the absence of medical record validation, could represent ocular hypertension in addition to frank glaucoma. Additional follow-up with validation is needed to identify the type of glaucoma affected.

See full text article attached.

 

Omega-3 Fatty Acids Lower Eye Pressure

Submitted by dave on Sun, 08/16/2009 - 9:15pm

Read the summary of University of Melbourne's Department of Optometry and Vision Sciences study on an association between dietary omega-3 fatty acid intake, age, and intraocular pressure. Another proof of beneficial effect of taking fish oil to strengthen and support healthy eyes and vision.

Some quick thoughts about dry eyes

Submitted by dave on Sun, 08/16/2009 - 9:01pm

For dry eyes, here are some things to consider:

  1. Take flaxseed and/or fatty acid supplements. I use Neptune Krill Oil, Cod Liver Oil and DHA supplements. Here are a couple links to more info:
    http://fiteyes.com/Krill-Oil-Benefits-for-Vision-Better-Than-Fish-Oil
    http://fiteyes.com/fish-oils-for-vision
  2. dry eyes drops

    Consume more Omega-3 fatty acids (and less Omega-6 fatty acids). Ideally the ratio between these two types of fatty acids in your diet should be around 1:1. In the typical western diet, people consume 20 times more Omega-6 fatty acids.The Omega-3 fatty acids can decrease the viscosity of tears and normalize the function of the tear glands. Sources of Omega-3 fatty acid in your diet include walnuts and soybeans.

  3. Use castor oil eye drops. An old folk remedy for dry eyes, castor oil can be found in many commercial eye drops. I simply can add one drop of organic castor oil to my eyes at bedtime, but you can do it twice daily. Use an eye dropper.
  4. Look into the supplement N-acetylcysteine (NAC). Some researchers believe this amino acid stabilizes tear production. The usual does is 100 mg three times a day. I don't personally use this, but there has also been discussion that it would be helpful for glaucoma and other eye conditions.
  5. Check out Taran's advice about coconut oil here: http://fiteyes.com/coconut-oil

Aerobic exercise and intraocular pressure in normotensive and glaucoma patients

Submitted by dave on Fri, 08/14/2009 - 2:31pm

runningBackground

With the increasing number of people participating in physical aerobic exercise, jogging in particular, we considered that it would be worth knowing if there are should be limits to the exercise with regard to the intraocular pressure (IOP) of the eyes. The purpose of this study is to check IOP in healthy and primary glaucoma patients after aerobic exercise.

Methods

Free Glaucoma Eye Drops for Newly Unemployed Americans

Submitted by dave on Sat, 08/08/2009 - 1:17pm

The Pfizer MAINTAIN program helps eligible people in financial need continue to get their Pfizer medicines — including the glaucoma drug Xalatan® — if they have recently become unemployed and do not have prescription coverage. Beneficiaries of the program will get their Pfizer medicines for free for up to a year or until they become re-insured (whichever comes first).

Eligibility

Individuals and their immediate family members are eligible for this program if:

The search for neuro-protective agents for the treatment of glaucoma

Submitted by dave on Thu, 08/06/2009 - 5:00pm

There was an interesting article on BBC today about recent advances in neuroprotection for glaucoma. Here are some highlights from the article:

optic nerve fundus photoLead researcher Dr Stefano Bonini said: "Although neuroprotection in glaucoma has already been attempted with several compounds, this is the first time that an improvement in visual function is observed in patients with advanced optic nerve damage."

David Wright, chief executive of the International Glaucoma Association, warned against drawing firm conclusions from such a small study - but said the results were encouraging.

He said: "There have been many false dawns in the search for neuro-protective agents for the treatment of glaucoma and it is a feature of research on other compounds that early promise does not always translate into clinical effectiveness when larger studies are undertaken.

"However, this research would seem to indicate both effectiveness and acceptability as to the means of drug delivery.

"If these early indications are carried through to wider trials and there are no other problems, then this has the potential to open a completely new method of treating glaucoma and of preventing unnecessary visual loss in the future."

No doubt that sunbeds cause cancer

Submitted by dave on Tue, 07/28/2009 - 7:21pm

I just read this news item:

http://news.bbc.co.uk/2/hi/uk_news/8172690.stm

There is no doubt using a sunbed or sunlamp will raise the risk of skin cancer, say international experts.

Previously, the International Agency for Research on Cancer (IARC) assessed sunbeds and sunlamps as "probably carcinogenic to humans".

But it now says their use is definitively "carcinogenic to humans".

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Better Computer Monitors Coming Soon?

Submitted by dave on Mon, 07/20/2009 - 9:21pm

Many people with vision problems are eagerly awaiting better computer monitors. The ideal monitor would be based on reflective technology (meaning it doesn't emit light), allowing you to read it in normal daylight or even bright sunlight. Ebook readers generally use this technology, but computer monitors do not.

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Excitement raises eye pressure?

Submitted by dave on Sat, 07/11/2009 - 10:03pm

Question: I just had a really fun and exciting time and I measured my intraocular pressure afterwards (via self-tonometry). After this stimulating time, the intraocular pressure was average 25pts. It is usually only 16 this time of night.

Therefore, I think adrenalin plays a big part in my elevated eye pressures.

Does Licorice Increase Intraocular Pressure?

Submitted by dave on Sun, 06/28/2009 - 7:19pm

Does Licorice Increase Intraocular Pressure? I attempted to answer this question for a friend today.

Here is the information I have so far:

1. Glycyrrhizin is the main sweet tasting compound from liquorice root.

2. A derivative of glycyrrhizin is glycyrrhetinic acid.

3. Glycyrrhetinic acid inhibits 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1; 11βHSD1 is an NADPH-
dependent enzyme highly expressed in the liver and adipose tissue).

Nutritional Supplements: Too Much of a Good Thing by Dr. Reader

Submitted by dave on Sun, 06/28/2009 - 6:08pm

The information in the Review of Ophthalmology article by August L. Reader III, MD, FACS, San Francisco, is very interesting. However, as you read it keep in mind that what is presented is a mix of strongly supported evidence and speculation. For example, section on carrot-family herbs contains a lot of pure speculation. It is still interesting and I have presented a portion of the article here.

Click this link to read the whole article: http://www.revophth.com/index.asp?page=1_479.htm

Can The Optic Nerve Regenerate Itself?

Submitted by dave on Sat, 06/20/2009 - 8:05pm

“The recent discovery that the hippocampus is able to generate new neurons throughout a human’s lifespan has changed the way we think about the mechanisms of psychiatric disorders and drug addiction,” says Wen Jian and colleagues in a study published in the Journal of Clinical Investigation in 2005.

The body's capacity to regenerate always surprises us. Personally, I am confident that the optic nerve can naturally regenerate itself.

 

Lowering of intraocular pressure by wild carrot seed extract in rabbits

Submitted by dave on Fri, 06/19/2009 - 7:53am

In normotensive rabbits topical application of Daucus carota seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline.

As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP.

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