Does Licorice Increase Intraocular Pressure? I attempted to answer this question for a friend today.
Here is the information I have so far:
1. Glycyrrhizin is the main sweet tasting compound from liquorice root.
2. A derivative of glycyrrhizin is glycyrrhetinic acid.
3. Glycyrrhetinic acid inhibits 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1; 11βHSD1 is an NADPH-
dependent enzyme highly expressed in the liver and adipose tissue).