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How emotions affect eye pressure--Excitement

Submitted by dave on Fri, 05/07/2010 - 10:41pm

Excitement of winningI learned about emotions and eye pressure, in part, by watching my favorite sports and measuring my eye pressure over a period of years. See Watching Tour de France Raises IOP

Here is what I discovered after monitoring my eye pressure before, during and after watching sports over a period of several years.

  • If you watch a sports event that you don't care about at all, it has almost no effect on your eye pressure.
  • If you watch a sports event where your ego is caught up in the outcome of the event (i.e., you are attached to an outcome, such as your team should win) the excitement will raise your IOP.
  • If you watch a sports event where you appreciate the action, enjoy the skill of the participants, etc. and are not attached to the outcome, your intraocular pressure will be largely unaffected.

 

Nitric Oxide compound lowers eye pressure more than glaucoma drugs like Xalatan alone

Submitted by dave on Mon, 04/26/2010 - 8:03pm

 A Novel Nitric Oxide Releasing Prostaglandin Analog, NCX 125, Reduces Intraocular Pressure in Rabbit, Dog, and Primate Models of Glaucoma

 

Abstract

 

Purpose: Nitric oxide (NO) is involved in a variety of physiological processes including ocular aqueous humor dynamics by targeting mechanisms that are complementary to those of prostaglandins. Here, we have characterized a newly synthesized compound, NCX 125, comprising latanoprost acid and NO-donating moieties.

Methods: NCX 125 was synthesized and tested in vitro for its ability to release functionally active NO and then compared with core latanoprost for its intraocular pressure (IOP)-lowering effects in rabbit, dog, and nonhuman primate models of glaucoma.

Results: NCX 125 elicited cGMP formation (EC50 = 3.8 ± 1.0 μM) in PC12 cells and exerted NO-dependent iNOS inhibition (IC50 = 55 ± 11 μM) in RAW 264.7 macrophages. NCX 125 lowered IOP to a greater extent compared with equimolar latanoprost in: (a) rabbit model of transient ocular hypertension (0.030% latanoprost, not effective; 0.039% NCX 125, ∆max = −10.6 ± 2.3 mm Hg), (b) ocular hypertensive glaucomatous dogs (0.030% latanoprost, ∆max= −6.7 ± 1.2 mm Hg; 0.039% NCX 125, ∆max = −9.1 ± 3.1 mm Hg), and (c) laser-induced ocular hypertensive non-human primates (0.10% latanoprost, ∆max = −11.9 ± 3.7 mm Hg, 0.13% NCX 125, ∆max = −16.7 ± 2.2 mm Hg). In pharmacokinetic studies, NCX 125 and latanoprost resulted in similar latanoprost-free acid exposure in anterior segment ocular tissues.

Conclusions: NCX 125, a compound targeting 2 different mechanisms, is endowed with potent ocular hypotensive effects. This may lead to potential new perspectives in the treatment of patients at risk of glaucoma.

 

List of all the things that affect eye pressure

Submitted by dave on Fri, 04/23/2010 - 12:30am

I'd like to ask everyone with a tonometer and good eye pressure data to contribute comments to this post. What factors have we identified that affect eye pressure? I'm going to start the list informally with things that come off the top of my head. I'll revise and refine this list based on feedback from people with tonometers and good data. Thank you!

Reduces Eye Pressure

Are herbs effective for lowering eye pressure?

Submitted by dave on Thu, 04/22/2010 - 8:16pm

My original expectation was that elevated intraocular pressure would respond to herbs (and vitamins) in the same way every other physical complaint I had encountered in my life responded.

My initial strategy for managing my IOP was a strategy built on herbs and supplements. That strategy was a complete 100% total failure.

Doing things slowly in a fast world

Submitted by dave on Thu, 04/22/2010 - 7:30pm

The entire following blog post was intially written as a private email to a friend of mine. I decided to share it here.

I grew up doing fast things in a fast way. I raced motorcycles -- and I have always loved anything fast. But I also tried to accomplish the maximum possible number of things each day and I always pushed myself to do things quicker or more efficiently. Then I developed glaucoma.

As I have gotten to know myself more intimately (thanks in part to self-tonometry) I have realized that I actually like to take my time. I enjoy doing things in a non-rushed manner. You could even say that I enjoy being slow! (Something I never would have admitted to myself in my days of racing, even in my most private thoughts.) Even today, I still have a great admiration for people who do things quickly, as if this is an inherently superior way of being.

But I now know that I like to take my time doigo slow to reduce eye pressureng things. I still enjoy efficiency. But sometimes it is more efficient to delay the next project's start and finish what was started rather than have to terminate it due to an artificial deadline and then pick it up again at a later time. I like going deep into things (whether discussions, research or building software) and having the time to do it well. And I have found that sometimes I even enjoy doing something in a completely inefficient manner (saying that still sounds sacrilegious). Sometimes I enjoy just plain being slow! (What have I just said! My gosh!)

Are handheld or portable tonometers appropriate for home eye pressure monitoring?

Submitted by dave on Thu, 04/22/2010 - 12:29pm

In any tonometer (based on today's technology), you can have some, but not all of, the following:

  • ease of use
  • accuracy (reliability and validity of data)
  • low cost
  • portability

handheld portable tonometerPeople tend to give a priority to portability and low cost. New products aimed at this feature set have recently been announced. Does it make sense to utilize those devices for self-tonometry?

We have to agree that any trade off that doesn't include reliability and validity of IOP data invalidates the whole endeavor of self-tonometry. Not only is it meaningless to do it if the data is not of sufficient quality upon which to make important decisions, but it could actually be detrimental to do self-tonometry in that case.

With today's technologies, portability entails user-alignment (in the context of self-tonometry). Proper user-alignment to produce a valid measurement, by definition, depends upon user skill as well as various specific conditions of each measurement. User-alignment, regardless of the tonometer, is difficult! (User-alignment is defined as the operator of the tonometer having to align the tonometer with the eye manually. Alignment is a very precise process requiring a steady hand, good eyesight, training and practice.)

Therefore, the requirement of user-alignment conflicts with the requirement of reliability and validity of IOP data. We cannot guarantee reliability and validity of IOP data when variable user skills are required to produce that data.

If any decent ophthalmologist or scientist (or intelligent thinker) considers a set of IOP data, they must consider how the data was obtained. If patient skill played a critical role in producing that data, as it does when user-alignment is required, the clear thinking person will immediately discount that data. Therefore, the self-tonometrist's efforts may not produce much of value.

Continuous Positive Airway Pressure Therapy Is Associated with an Increase in Intraocular Pressure in Obstructive Sleep Apnea

Submitted by dave on Thu, 04/22/2010 - 9:41am

PURPOSE. Several reports have demonstrated an association between glaucoma and obstructive sleep apnea (OSA), though the origin of this association remains unknown. In the present study, the influence of OSA and continuous positive airway pressure (CPAP) therapy on intraocular pressure (IOP) and ocular perfusion pressure (OPP) was examined.

METHODS. IOP, blood pressure, and pulse rate were measured every 2 hours during 24-hour sessions in 21 patients with newly diagnosed OSA. A first series of measurements was performed before CPAP therapy, and a second series was performed 1 month after the initiation of CPAP therapy. OPP was then calculated.

My new tonometer is here finally!!!

Submitted by dave on Tue, 04/20/2010 - 11:11pm

best tonometer for home eye pressure monitoringA lot of new people are joining our group for home eye pressure monitoring (self-tonometry). Please allow me to welcome all the new users and share a few thoughts about what to do when your new tonometer arrives.

It is always best to leave the job of making judgments about your eye pressure -- in the context of your health care -- to your doctor. This is not just a disclaimer!

Part of the skill of managing your eye pressure effectively is to not think about it the way a doctor would. If you think there is a medical emergency, by all means call your doctor. But in general the best thing you can do is measure as often as possible and do everything you can to avoid playing doctor.

Do not diagnose your own intraocular pressure. Don't think about what it may mean in terms of glaucoma. This is a powerful skill, not a cop out. This is a powerful skill because we have strong evidence that one's state of mind affects one's eye pressure. You will begin to see evidence of this when you start monitoring your eye pressure.

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Some glaucoma specialists are taking magnesium supplementation seriously

Submitted by dave on Thu, 04/15/2010 - 1:08pm

The effect of oral magnesium therapy on visual field and ocular blood flow in normotensive glaucoma

Note these conclusions! Also note that Josef FLAMMER, Professor and Head, Department of Ophthalmology, University Hospital Basel (Switzerland), recommends magnesium supplementation (so I am told).

Purpose. To evaluate the effect of oral magnesium therapy on ocular blood flow and visual field perimetry indices in patients with normotensive glaucoma (NTG).

Preview of the Icare ONE handheld tonometer for home eye pressure monitoring

Submitted by dave on Fri, 04/09/2010 - 11:44am

My evaluation Icare ONE tonometer arrived today. I will compare it to:

    * Icare TA01i
    * Reichert 7CR Tonometer
    * Pascal Dynamic Contour Tonometer
    * Ocular Response Analyzer
    * Reichert AT555 Tonometer
    * maybe another one or two tonometers...

Look for a full review in the near future on FitEyes.com. UPDATE: I have decided not to publish my review of the Icare ONE at this time. Please read Are handheld or portable tonometers appropriate for home eye pressure monitoring?

Let me offer an analogy. If I were reviewing golf clubs, I would not include a review of a baseball bat. A baseball bat is not appropriate for playing golf. During the process of evaluating the Icare ONE, I came to a broader conclusion about all handheld tonometer and their appropriateness for self-tonometry (home eye pressure monitoring). Therefore, I feel it is better to have that general discussion first. You can read my thoughts here: Are handheld or portable tonometers appropriate for home eye pressure monitoring?

There is a related discussion on the Icare ONE here: New iCare ONE Tonometer Designed for Home Eye Pressure Monitoring

For now, here are some pictures of my evaluation Icare ONE tonometer.

Just arriving via FedEx (below). Some tonometers it will be evaluated against are shown in the background.

Icare ONE home eye pressure monitoring tonometer

 

Cure for glaucoma which leads to blindness may be on its way: lymphatics found in eye

Submitted by dave on Wed, 04/07/2010 - 8:54am

Cure for glaucoma soon, says new research
newkerala.com/nkfullnews-1-125456.html

October 6th, 2009 SindhToday
Toronto, Oct 6 (IANS) Cure for glaucoma which leads to blindness may be on its way.

Canadian researchers have discovered an unidentified form of circulation in the human eye which may provide important clues to glaucoma.

The human eye is considered to lack lymphatics – a circulation responsible for pumping fluid and waste out of tissues.

But now researchers at the Universityof Toronto and the local St Michael’s Hospital say the inability to clear that fluid from the eye is linked to glaucoma which currently affects over 66 million people worldwide.

Effect of Sleeping Posture on Intraocular Pressure

Submitted by dave on Sun, 04/04/2010 - 1:55pm

A research study presented as a "poster" at ARVO 2010 indicated that the position of one's head (and body) during sleep can have an effect on intraocular pressure. For example, your eye pressure may be lower if you sleep on your back compared to sleeping on your side. (Furthermore, in my own experience, sleeping on your stomach may be the worst for IOP.)

Not discussed in this particular study was any difference in intraocular pressure between eyes. There is some evidence that if you sleep on your left side, intraocular pressure in the left eye could be higher.

Eating eggplant does NOT reduce eye pressure in our tests

Submitted by dave on Tue, 03/23/2010 - 4:20pm

It has come to my attention that a number of people are reading the headline from our discussion about eggplant and intraocular pressure and coming to a conclusion without actually reading the article. That's not a good idea in this case.

Please read the article and the comments. Here's the link: Eating eggplant reduces eye pressure

Effect of Sleeping in a Head-Up Position on Intraocular Pressure in Patients with Glaucoma

Submitted by dave on Wed, 03/03/2010 - 2:28pm

I am reading this study now. I like the fact that they did investigate ocular perfusion pressure (OPP) while monitoring the intraocular pressure (IOP) during this study, and that they checked IOP in the sleeping position (rather than sitting the patient up). So, with a quick glance, the methodology looks acceptable to me.

Purpose: To determine whether a 30-degree head-up sleeping position decreases nocturnal intraocular pressure (IOP) compared with lying flat in patients with glaucoma.

Intraocular Pressure in a Spiritual Context

Submitted by dave on Wed, 02/24/2010 - 9:59am

Recently here on FitEyes, readers have asked about the relationship between intraocular pressure about meditation. That prompted me to write this post about some of the broader spiritual aspects of what I do as well as how I view intraocular pressure in my own life and in my work as a Serene Impulse teacher.

Kindness As A Tool for Managing Eye Pressure

Submitted by dave on Wed, 01/20/2010 - 1:26pm

Yesterday I saw some discussions that reminded me of the profound discovery I made several years ago in my own intraocular pressure data. I observed, time and time again, that simply disagreeing with another individual in an online forum would raise my intraocular pressure. (This effect does not require arguing -- simply disagreeing in a polite manner is often enough.) This is a universal phenomenon.

Panic attacks, adrenal exhaustion, eye pressure and consciousness

Submitted by dave on Sun, 01/17/2010 - 2:01pm

FitEyes post about the healing power of consciousnessLow blood pressure can be a problem for glaucoma patients because it results in insufficient blood supply to the optic nerve.

A lot of glaucoma patients suffer from anxiety, stress, panic attacks and other similar issues. Those issues lead to adrenal fatigue and adrenal exhaustion. And adrenal fatigue/exhaustion can lead to low blood pressure (hypotension).

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