glaucoma medications

My experiences with self-tonometry

Submitted by Anonymous (not verified) on Tue, 05/04/2010 - 3:00pm

I have been part of FitEyes since 2006 and I bought my tonometer in late 2006. I've been using it almost every day since then. I am very calm about measuring my IOP perhaps 2 or 4 times a day (or sometimes not at all if away from home).

While away from home I use drops 'just in case'; at home I might go for several days with no drops while I monitor my IOP with my tonometer .

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Rescula Discussion

Submitted by dave on Mon, 06/03/2013 - 8:56am

A FitEyes member asked:   

I wonder if anyone of you has ever tried Rescula. This is a new product for glaucoma.

It’s actually old

The FDA approved Rescula in 2000 for the treatment of open-angle
glaucoma and ocular hypertension. The drug was taken off the market in
the United States in 2005 (apparently for commercial reasons). But the
commercialization rights were licensed in 2009 to Sucampo
Pharmaceutials, Inc. Sucampo then submitted a supplemental New Drug
Application to the FDA and relaunched the product.

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Nitric Oxide compound lowers eye pressure more than glaucoma drugs like Xalatan alone

Submitted by dave on Mon, 04/26/2010 - 8:03pm

 A Novel Nitric Oxide Releasing Prostaglandin Analog, NCX 125, Reduces Intraocular Pressure in Rabbit, Dog, and Primate Models of Glaucoma

 

Abstract

 

Purpose: Nitric oxide (NO) is involved in a variety of physiological processes including ocular aqueous humor dynamics by targeting mechanisms that are complementary to those of prostaglandins. Here, we have characterized a newly synthesized compound, NCX 125, comprising latanoprost acid and NO-donating moieties.

Methods: NCX 125 was synthesized and tested in vitro for its ability to release functionally active NO and then compared with core latanoprost for its intraocular pressure (IOP)-lowering effects in rabbit, dog, and nonhuman primate models of glaucoma.

Results: NCX 125 elicited cGMP formation (EC50 = 3.8 ± 1.0 μM) in PC12 cells and exerted NO-dependent iNOS inhibition (IC50 = 55 ± 11 μM) in RAW 264.7 macrophages. NCX 125 lowered IOP to a greater extent compared with equimolar latanoprost in: (a) rabbit model of transient ocular hypertension (0.030% latanoprost, not effective; 0.039% NCX 125, ∆max = −10.6 ± 2.3 mm Hg), (b) ocular hypertensive glaucomatous dogs (0.030% latanoprost, ∆max= −6.7 ± 1.2 mm Hg; 0.039% NCX 125, ∆max = −9.1 ± 3.1 mm Hg), and (c) laser-induced ocular hypertensive non-human primates (0.10% latanoprost, ∆max = −11.9 ± 3.7 mm Hg, 0.13% NCX 125, ∆max = −16.7 ± 2.2 mm Hg). In pharmacokinetic studies, NCX 125 and latanoprost resulted in similar latanoprost-free acid exposure in anterior segment ocular tissues.

Conclusions: NCX 125, a compound targeting 2 different mechanisms, is endowed with potent ocular hypotensive effects. This may lead to potential new perspectives in the treatment of patients at risk of glaucoma.

 

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EYE DROPS -- DANGERS LURK WITHIN By Bill Sardi

Submitted by Amanda on Thu, 04/15/2010 - 11:07am

Your eyes bother you. So you go down to the drug store and buy a bottle of artificial tears. There are so many brands you really don't know which one is best. Or you trust your eye doctor who may prescribe an eye drop for glaucoma or who recommends an over-the-counter eye drop for your dry, red, itchy, burning eyes. To keep the ingredients from spoiling, manufacturers add preservatives. It is these preservatives, even in doses as small as 1/10th of 1 percent, that are a cause for concern.

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Applying eyedrops my way

Submitted by jarek on Fri, 05/15/2009 - 12:06am

Hello to everyone with my first post. I'd like to pass big thanks to the founder(s) and maintainter(s) of this site (by the way: page lacks kind of "who we are" link). I'm happy to join your community. I hope I'll be able to give it as much as I can take from it.

I'm on low but frequent doses of pilocarpine for a few months. This drops show their effect in about 30 minutes, so it's easy to tell if they are working. So finding a way to make them work always wasn't very difficult.

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The Different Ways To Perform Home Eye Pressure Monitoring

Submitted by dave on Mon, 06/09/2008 - 7:17pm

I want to highlight three different approaches to performing home eye pressure monitoring (self-tonometry). Normally, I focus most of my attention in my blog on the approach I use. However, I thought it would be educational to contrast my approach with two other approaches. I'll discuss each one, but to get us started I would like to give each method a name as shown below:

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Ocufors - Is it Ayurvedic?

Submitted by dave on Sat, 05/24/2008 - 2:02pm

In 2006 I wrote about the news that Ocufors, a plant-based pharmaceutical product for glaucoma, had received regulatory approval from India's equivalent of the US FDA (the Drugs Controller General of India - DCGI).

Ocufors is a natural, plant-derived product that has been found to be 30% more effective at reducing intraocular pressure than existing glaucoma drugs, according to its manufacturer.

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