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Evaluation of Carotid Intima Media Thickness and Renal Artery Resistive Index in Patients With Pseudoexfoliation Syndrome: A Prospective Case-Control Study

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: CIMT increases in PES patients and also the renal artery resistance index has a tendency to increase. Patients with PES should be informed about potential systemic consequences of this syndrome. (Source: Journal of Glaucoma)
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Evaluation of Blebs After Filtering Surgery With En-Face Anterior-Segment Optical Coherence Tomography: A Pilot Study

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To compare characteristics of functioning blebs (FBs) and nonfunctioning blebs (NFBs) with en-face spectral-domain optical coherence tomography (OCT). Methods: We evaluated 41 blebs of 38 patients after a first-time trabeculectomy. Eyes were classified into 2 groups: FBs (22 eyes) and NFBs (19 eyes). En-face OCT images were analyzed semiquantitatively for the density of intraepithelial microcysts (0 to 3), internal fluid-filled cavity (0 to 3), and bleb vascularization (0 to 2). Presence of conjunctival fibrosis and visualization of the scleral flap were also analyzed. Results: FBs showed significantly more intraepithelial microcysts than did NFBs: the mean grading of microcyst density was 1.86 for FBs and 0.11 for NFBs (P (Source: Journal of Glaucoma)
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The Conjunctiva in Normal Tension Glaucoma Patients is Thinner Than in Primary Open-Angle Glaucoma Patients: A Comparative Histologic Study

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: The conjunctiva in patients with NTG was thinner than in POAG patients. This finding is an additional feature in the pattern of thinner ocular structures in patients with NTG. (Source: Journal of Glaucoma)
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Lamina Cribrosa Depth is Associated With the Cup-to-Disc Ratio in Eyes With Large Optic Disc Cupping and Cup-to-Disc Ratio Asymmetry

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To investigate the lamina cribrosa (LC) depth and its relationship with the cup-to-disc ratio (CDR) in the eyes with generalized increased optic disc cupping and CDR asymmetry. Methods: Glaucoma suspect subjects with a CDR≥0.7, CDR asymmetry ≥0.2 in the absence of visual field (VF) loss, and normal control subjects were enrolled. The optic nerve head was imaged using the enhanced depth imaging modes of Spectralis optical coherence tomography. The LC depth was determined at the mid-horizontal, and the superior and inferior mid-peripheral regions of the optic nerve head. Results: Disc area and CDRs were larger in the glaucoma suspect group compared with the control group (P (Source: Journal of Glaucoma)
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Trabeculectomy With Moorfields Conjunctival Closure Technique Offers Safety Without Astigmatism Induction

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: Trabeculectomy with a fornix-based conjunctival flap closed by 4 corneal groove-embedded sutures results in a low complication rate. This safe suturing technique induces a transient shift of with-the-rule astigmatism, reverting to the preoperative values within 3 months of surgery. Adjustments to refractive correction are recommended to be postponed until after this period. (Source: Journal of Glaucoma)
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Repeatability of Spectral Domain Optical Coherence Tomography Measurements in High Myopia

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: Repeatabilities of most of the SDOCT parameters in high-myopic subjects were good and comparable to that of emmetropic subjects. This suggests that SDOCT can be useful for following up high-myopic glaucoma patients to detect progression. (Source: Journal of Glaucoma)
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Evaluation of Nonmydriatic Hand-held Optic Disc Photography Grading in the Philadelphia Glaucoma Detection and Treatment Project

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: Nonmydriatic, monoscopic disc photographs obtained by a hand-held camera had only moderate disc grading reproducibility. This could be due to a reduced quality of images, making interpretation more challenging, due to taking photographs through small pupils by a hand-held camera and the high percentage of patients with significant cataracts. (Source: Journal of Glaucoma)
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The Prevalence and the Incidence of Diagnosed Open-Angle Glaucoma and Diagnosed Angle-Closure Glaucoma: Changes From 2001 to 2010

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To explore the trends in diagnosed open-angle glaucoma (OAG) and diagnosed angle-closure glaucoma (ACG) in Taiwan during the period of 2001 to 2010. Materials and Methods: Data were sourced from the National Longitudinal Health Insurance Database 2000 (LHID2000). The study population comprised all patients with a diagnosis of OAG or ACG (International Classification of Diseases, 9th Revision, Clinical Modification codes 365). Patients were stratified by their sex and age; differences in standardized incidence rates were compared between the stratified groups. Results: Throughout the study period, the prevalence of diagnosed OAG (slope=0.18, P (Source: Journal of Glaucoma)
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Relationship Between Body Mass Index and Intraocular Pressure in Men and Women: A Population-based Study

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To assess the possibility of a relationship between body mass index (BMI) and intraocular pressure (IOP) in both men and women. Materials and Methods: A retrospective cross-sectional analysis of a database from a screening center in Israel which assessed 18,575 subjects, within an age range 20 to 80 years. Results: The mean (±SD) age of the study sample was 46 (±10) years, 68% were men. A positive linear correlation was found between BMI and IOP for both men and women (r=0.166, P (Source: Journal of Glaucoma)
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Glaucoma and the Origins of Its Name

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: In ancient Greek medical literature, Glaucoma had a significant place among ocular diseases. The origin of its name could be traced back to Homeric times and could be connected to the ancient belief of a primitive folk about the apotropaic role of animals against diseases, which in this case is represented by the superstitious role of the owl. (Source: Journal of Glaucoma)
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No Evidence of Association of Heterozygous Galactosylceramidase Deletion With Normal-Tension Glaucoma in a Korean Population

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: This is the first copy-number variation study of the GALC gene in the Korean population with NTG. We demonstrated that a heterozygous GALC deletion does not play a significant role in the pathogenesis of NTG in a representative clinic-based population of South Koreans, unlike whites. (Source: Journal of Glaucoma)
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Effects of Phacoemulsification Combined With Goniosynechialysis on Primary Angle-closure Glaucoma

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: The treatment of phacoemulsification, intraocular lens implantation, and goniosynechialysis is safe and effective for patients with primary angle-closure glaucoma and cataract. (Source: Journal of Glaucoma)
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CYP1B1 and MYOC Mutations in Vietnamese Primary Congenital Glaucoma Patients

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: Five out of 30 families with PCG (16.7%) had disease attributable to CYP1B1 alterations suggesting that CYP1B1 is not the major gene causing PCG in Vietnamese unlike in the case of Arab or Romany patients. This percentage is similar to that detected in studies of Japanese and Chinese patients with sporadic PCG. PCG has proven to be an ocular disease of genetic heterogeneity, calling for further studies to identify novel genes causing this disease. (Source: Journal of Glaucoma)
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Effect of Axial Length on Macular Ganglion Cell Complex Thickness and on Early Glaucoma Diagnosis by Spectral-Domain Optical Coherence Tomography

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: The inferior mGCC was thinner in eyes with longer AL. The accuracy of the diagnosis with the SD-OCT built-in normative database for early glaucoma was not improved significantly by the correction of the AL-associated magnification in highly myopic eyes. Evaluation of highly myopic eyes with the nonhighly myopic normative database can lead to misdiagnosis. (Source: Journal of Glaucoma)
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Initial Experience With the New Ahmed Glaucoma Valve Model M4: Short-term Results

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To evaluate the clinical outcomes of the new Ahmed glaucoma valve (AGV) model M4. The device consists of a porous polyethylene shell designed for improved tissue integration and reduced encapsulation of the plate for better intraocular pressure (IOP) control. Methods: Medical records of patients with an AGV M4 implantation between December 1, 2012 and December 31, 2013 were reviewed. The main outcome measure was surgical failure, defined as either (1) IOP21 mm Hg and/or (Source: Journal of Glaucoma)
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Effect of Laser Peripheral Iridotomy on Anterior Chamber Angle Anatomy in Primary Angle Closure Spectrum Eyes

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: TICV is a useful parameter to quantitatively measure the effectiveness of LPI in the treatment of eyes with PAC spectrum disease. (Source: Journal of Glaucoma)
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Fluctuations of the Intraocular Pressure in Pseudoexfoliation Syndrome and Normal Eyes Measured by a Contact Lens Sensor

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: We compared the fluctuation of the intraocular pressure (IOP) in patients with pseudoexfoliation syndrome (PE) and individuals with normal healthy eyes. We measured continuous IOP using a SENSIMED Triggerfish contact lens sensor (CLS). Methods: Eleven eyes with PE and 11 healthy eyes were examined. In all 22 participants, the IOP fluctuation was measured continuously for 24 hours with a CLS. The CLS could measure every 5 minutes. We evaluated IOP fluctuations over the 24-hour period separately for diurnal IOP and nocturnal IOP. We also identified each participant’s maximum value. Changes in the corneal thickness and the corneal curvature were measured before and after the CLS use with anterior-segment optical coherence tomography. Results: The mean IOP within the PE eyes was 2...
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Correlations Between the Individual Risk for Glaucoma and RNFL and Optic Disc Morphometrical Evaluations in Ocular Hypertensive Patients

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Purpose: To assess the correlation between the 5-year risk of developing primary open-angle glaucoma (POAG) [on the basis of the Ocular Hypertension Treatment Study (OHTS)-European Glaucoma Prevention Study (EGPS) model] and optic nerve head and retinal nerve fiber layer (RNFL) indices as evaluated by optical coherence tomography (Stratus OCT), scanning laser polarimetry (GDx ECC), and confocal laser ophthalmoscopy [Heidelberg Retinal Tomograph (HRT) III] in ocular hypertensive (OHT) individuals. Participants and Methods: Sixty-eight OHT individuals with the untreated intraocular pressure in both eyes between 22 and 32 mm Hg, an ophthalmoscopically normal optic disc with a cup/disc ratio asymmetry between the 2 eyes of ≤0.2, and a visual field with glaucoma hemifield test within normal ...
Categories: News

Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: Our meta-analysis found no significant difference in the choroidal thickness both under the fovea and around the optic nerve head between OAG patients and controls. On the basis of the anatomic features of blood supply in optic nerve head, it is plausible that the choroidal thickness is not an appropriate parameter to evaluate the damage of OAG, and choroidal thinning may not be an important component of glaucomatous optic neuropathy. (Source: Journal of Glaucoma)
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Early Glaucoma Screening Using the Ibopamine Provocative Test

Journal of Glaucoma - Fri, 04/29/2016 - 10:13am
Conclusions: The ibopamine test showed an adequate diagnostic performance to detect individuals at increased risk of glaucoma in a very early stage of the disease. While further studies are required, the provocative ibopamine test for the diagnosis of early glaucoma is promissory. (Source: Journal of Glaucoma)
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