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Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

Submitted by dave on Mon, 09/24/2018 - 2:52pm

Log in to download the full text paper.

Abstract


Aims

Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a new potentially important cause of increased cardiovascular risk. The purpose of this meta-analysis was to systematically estimate and quantify the association between TMAO plasma levels, mortality, and major adverse cardio and cerebrovascular events (MACCE).

China Study author Colin Campbell slaps down critic

Submitted by dave on Sun, 09/23/2018 - 1:55am

Introduction by Vegsource.com

There has recently been a flurry of discussion prompted by an article by raw-animal-product advocate Denise Minger, which criticizes The China Study and attacks its author, Dr. T. Colin Campbell. Minger questions Dr. Campbell's personal motives and attempts to impugn his character.

Dr. Campbell recently took time to review Minger's observations and respond. You can read Minger's original article below, linked at the start of Dr. Campbell's response.

Filed Under (tags):

Dr. Sinatra's comment regarding Coenzyme q10 in patients with end‐stage heart failure awaiting cardiac transplantation: A randomized, placebo‐controlled study

Submitted by dave on Thu, 09/20/2018 - 9:20pm

This is part of our discussion about publications by Stephen T. Sinatra M.D. I am attaching his publication, which is a letter to the editor in regard to another study. Log in to download the PDF, or use the link below to obtain it from Wiley Online Library.

Filed Under (tags):

Apolipoprotein E may be associated with elevated risk of glaucoma

Submitted by dave on Sun, 09/16/2018 - 9:34pm

Apolipoprotein E is the "Alzheimer's gene". It is also widely known to be important in cardiovascular disease. Now we see it may have some bearing on glaucoma (at least in some populations). Log in to download the full text paper and read the FitEyes member-only portion of this blog post (below).

Abstract

Epidemiological studies have evaluated the association between Apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism and glaucoma susceptibility. However, the published data are still inconclusive. The aim of the present study is to evaluate the impact of APOE gene ε2/ε3/ε4 polymorphism on glaucoma risk by using meta-analysis.

Methods

A comprehensive literature search of PubMed, EMBASE, Cochrane, Elsevier Science Direct and CNKI databases was conducted to identify relevant articles, with the last report up to January 5, 2014. Pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association by using the fixed or random effect model.

Results

Fifteen separate studies including 2,700 cases and 2,365 controls were included in the meta-analysis. We did not detect a significant association between APOE gene ε2/ε3/ε4 polymorphism and glaucoma in overall population (P > 0.0083). In Asians, we detected an association of the ε4ε4 genotype with elevated risk for glaucoma (OR = 5.22, 95% CI = 1.85-14.68, P = 0.002), mainly for primary open angle glaucoma (OR = 4.98, 95% CI = 1.75-14.20, P = 0.003).

Conclusions

The meta-analysis suggests that APOE gene ε4ε4 may be associated with elevated risk for primary open angle glaucoma in Asians. However, more epidemiologic studies based on larger sample size, case–control design and stratified by ethnicity as well as types of glaucoma are suggested to further clarify the relationship between APOE gene ε2/ε3/ε4 polymorphism and genetic predisposition to glaucoma.

Keywords: Glaucoma, APOE, Genetic, Meta-analysis

The Authoritative History of the Cholesterol Controversy by Daniel Steinberg

Submitted by dave on Thu, 09/13/2018 - 6:48pm

All five papers in the series. Log in to download.

Thematic review series: The Pathogenesis of Atherosclerosis
An interpretive history of the cholesterol controversy
by Daniel Steinberg
Department of Medicine, University of California–San Diego, La Jolla, CA

Evaluation of Chowdhury Meta-Analysis on the Association of Fatty Acids with Coronary Risk by Fred Pollack

Submitted by dave on Thu, 09/13/2018 - 6:10pm

This post has Fred Pollack's four papers attached. Log in to download. If you think you may not have time to read all 4 parts, I suggest reading Part 3 first. Part 3 alone may be sufficient to answer your questions.

1. A Preliminary Evaluation of Chowdhury Meta-Analysis on the Association of Fatty Acids with Coronary Risk: Part 1

2. Evaluation of Chowdhury Meta-Analysis on the Association of Fatty Acids with Coronary Risk, Part 2

On How to Reverse Atherosclerosis (Heart Disease) by Fred Pollack

Submitted by dave on Thu, 09/13/2018 - 5:27pm

Diet to Halt and Reverse Heart-Disease/Atherosclerosis Info

About 9 years ago, I did a deep dive into the diet/health medical research.  I was more concerned about heart disease and my wife Iris was more concerned about getting cancer.  The research clearly showed that a low-fat, whole-food plant-based diet addressed both issues.  We made the switch 9 years ago.  I have continued to read the peer reviewed research.

Study shows omega-3 levels better predictors of death risk than serum cholesterol

Submitted by dave on Wed, 09/12/2018 - 3:29pm

Results showed that the risk for death from any cause was reduced by about 33% comparing in participants with highest omega-3 blood levels

Study shows omega-3 levels are better predictors of risk for death than serum cholesterol

Micropipette Tips

Submitted by terry on Fri, 05/19/2017 - 4:20pm
 
Belann's email forum question of 5-17-2017:
Do those of you who use the micro pipette for eye drops use a new tip every time, or do you try to sterilize them and reuse them?   If you try to sterilize the tip, how do you do it?  
 
Barry wrote 5-19-2017:
I use a new one every time.  Too much hassle to try to sterilize and they are very inexpensive. 
 
David wrote 5-19-2017:

The cost of losing one's vision is far greater than the cost of buying a tonometer or of learning a proven meditation technique

Submitted by dave on Wed, 09/28/2016 - 1:16am

Most FitEyes discussion happens on our very active mailing list. If you want the latest news, subscribe to our mailing list.

I took part in a mailing list discussion today. A number of people asked me to post the following message on my blog for easy reference. For context I will include the comments I was responding to first, followed by my response. (I'm editing parts of this for privacy and clarity.)

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