trabecular meshwork

The two most important facts you should know about glaucoma

Submitted by dave on Mon, 08/29/2011 - 4:28pm

Trabecular Meshwork Cell (detail)

Trabecular Meshwork Cell (detail)

This is the winning image for North America -- IN Cell Image Competition. It shows the internal structure of a single trabecular meshwork cell.

In this image, DNA has been stained blue, so the large clumps of blue just above centre are the cell's nucleus. Red lines are filaments of actin spread throughout the cell, while the green patches at their tips are the focal adhesions.

TGF-beta2 induces senescence-associated changes in human trabecular meshwork cells

Submitted by dave on Sat, 06/19/2010 - 11:32am

Primary open-angle glaucoma (POAG) is one of the leading causes of blindness in the world. This optic neuropathy is characterized by an elevated intraocular pressure, which may be attributed to an increased resistence in the aqueous humor outflow pathways.

Histological studies have demonstrated that primary open-angle glaucoma is associated with pathological changes in the trabecular meshwork (TM).

Recent investigations have revealed an accumulation of aged cells in the outflow pathways of glaucomatous eyes as compared to age-matched control eyes. Glaucoma is characterized by increased oxidative stress-induced aging of trabecular meshwork cells, thus leading to elevated intraocular pressure. The goal of this study was to analyse the role of TGF-β2 in the induction of cellular aging in cultured human trabecular meshwork cells.

The Trabecular Meshwork Can Contract And Regulate Fluid Outflow

Submitted by dave on Wed, 03/07/2007 - 1:58pm

Michael Wiederholt says, "Research in this laboratory has demonstrated that trabecular meshwork has contractile properties, is actively involved in outflow regulation..." Below is an abstract of one of the studies on this topic he helped author.

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