Palmitoylethanolamide Stimulates Phagocytosis by Microglial Cells without Inducing an Inflammatory Reaction

Summary: Palmitoylethanolamide (PEA), an endogenous lipid, increased phagocytosis of bacteria by microglial cells in vitro without a measurable proinflammatory effect. This allows the immune system to kill pathogens without harming nerve cells. Palmitoylethanolamide has been extensively tested clinically without observed severe side effects.

Molecular pathology of age-related macular degeneration

Submitted by dave on Fri, 05/29/2009 - 11:20am

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex interaction of genetic and environmental factors is thought to exist. AMD pathology is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium, and Bruch’s membrane, as well as, in some cases, alterations in choroidal capillaries.

Glaucoma, Inflammation and Oxidative Stress: An Attempt to Unify Recent News

Submitted by dave on Sun, 04/22/2007 - 3:40pm

This article is my attempt to unify some of what has been proposed about the mechanism underlying retinal ganglion cell (RGC) loss in glaucoma.

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