dietary supplements

Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders Including Glaucoma

Submitted by dave on Tue, 09/25/2018 - 1:44am

A wide range of neurodegenerative diseases (NDs), including Glaucoma, Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation.

Intervention strategies using plant-derived bioactive compounds have been offered as a form of treatment for these debilitating conditions, as there are currently no remedies to prevent, reverse, or halt the progression of neuronal loss. Rutin, a glycoside of the flavonoid quercetin, is found in many plants and fruits, especially buckwheat, apricots, cherries, grapes, grapefruit, plums, and oranges.

Pharmacological studies have reported the beneficial effects of rutin in many disease conditions, and its therapeutic potential in several models of NDs has created considerable excitement.

In the attached scientific paper, published in 2018, the authors summarize the current knowledge on the neuroprotective mechanisms of rutin in various experimental models of neurodegenerative diseases. The mechanisms of action reviewed in this article include reduction of proinflammatory cytokines, improved antioxidant enzyme activities, activation of the mitogen-activated protein kinase cascade, downregulation of mRNA expression of PD-linked and proapoptotic genes, upregulation of the ion transport and antiapoptotic genes, and restoration of the activities of mitochondrial complex enzymes.

Taken together, these findings suggest that rutin may be a promising neuroprotective compound for the treatment of glaucoma and other neurodegenerative diseases. Additionally, there are two studies on intraocular pressure and the combination of rutin plus forskolin (an herbal extract) which show this combination has the potential to reduce intraocular pressure.

Coleus Forskolii Extract 250 mg 60 caps by Paradise Herbs – FitEyes eStore

Rutin 450 mg 100 vcaps by NOW Foods – FitEyes eStore

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Creatine Supplementation Lowers Homocysteine in MTHFR Case

Creatine supplementation produces unique effects on homocysteine in individuals with MTHFR polymorphism, lowering plasma homocysteine levels instead of raising them in this case study. This is relevant to the methylation cycle and thus to glaucoma, as discussed in other artlcles on FitEyes.

SAMe Supplement Not Recommended for Glaucoma Patients

Excess methylation in the central nervous system (CNS) via SAMe (S-adenosylmethionine) may lead to neurodegeneration. Parkinson's Disease and glaucoma have enough similarities for glaucoma patients to be cautious about SAMe based on this report.
However, if one considers the biochemical pathways for synthesis of SAMe, there would seem to be a very good argument for glaucoma patients to eat a whole foods plant-based diet, which is naturally low in methionine, the direct precursor to SAMe.

Monitor and Compare Our Omega-3 Indexes - Here are my results!

Submitted by dave on Sun, 02/01/2015 - 2:16pm
I just had my Omega-3 Index tested by OmegaQuant, a leader in fatty acid analysis. It is a simple, inexpensive, home-based test. In this post I share my results and provide some discussion of what they mean in the context of glaucoma. I also share my thoughts on the supplements needed to achieve even better test results!

How to log in to the FitEyes eStore

I would like to answer a common question about accounts and passwords on FitEyes. Each of our websites has a separate login and password. For example, the blog ( and the store ( and the IOP database ( all have separate logins and passwords. There are technological reasons for this.

Fenugreek is anti-inflammatory, antioxidant and anti-arthritic


Trigonella foenum graecum (fenugreek) is an herbal medicinal plant used for the treatment of rheumatoid arthritis and inflammation.

The present study was designed to investigate the beneficial outcome of the plant T. foenum graecum on adjuvant-induced arthritis in albino rats. Ethanol extract of T. foenum graecum was tested against Freund's complete adjuvant-induced arthritis in rats.

Highest Natural Food Source of Palmitoylethanolamide (PEA, PeaPure) Discovered

Highest natural concentration of Palmitoylethanolamide (PEA, PeaPure) found in one of the oldest cultivated medicinal plants in the world! Up to 25% palmitoylethanolamide plus iron, potassium, calcium, selenium, copper, zinc, manganese, magnesium, thiamin (vitamin B1), folic acid, riboflavin (vitamin B2), pyridoxine (vitamin B6), niacin (vitamin B3), and vitamins A and C.

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