SAMe Supplement Not Recommended for Glaucoma Patients

Excess methylation in the central nervous system (CNS) via SAMe (S-adenosylmethionine) may lead to neurodegeneration. Parkinson's Disease and glaucoma have enough similarities for glaucoma patients to be cautious about SAMe based on this report.
However, if one considers the biochemical pathways for synthesis of SAMe, there would seem to be a very good argument for glaucoma patients to eat a whole foods plant-based diet, which is naturally low in methionine, the direct precursor to SAMe.

Homocysteine, B vitamins, MTHFR gene, and risk of glaucoma

Ophthalmology. 2012 Dec;119(12):2493-9. doi: 10.1016/j.ophtha.2012.06.025. Epub 2012 Aug 16.

Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis.



Association between MTHFR C677T polymorphism and primary open-angle glaucoma: A meta-analysis


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