genetics

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing

Background:

Mitochondrial DNA changes in glaucoma patients

Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients.

Genetic analysis showed that glaucoma patients belong to three groups. Fifty percent of the patients belonged to one group (the H2a2a lineage of the N-derived haplogroup*).

Molecular pathology of age-related macular degeneration

Submitted by dave on Fri, 05/29/2009 - 11:20am

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex interaction of genetic and environmental factors is thought to exist. AMD pathology is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium, and Bruch’s membrane, as well as, in some cases, alterations in choroidal capillaries.

Glaucoma and genetics: Is DNA the Key?

Submitted by dave on Wed, 02/13/2008 - 12:43am

Obviously, genetics are an important factor in how we develop and age. However, genetics are probably one of the most over rated-factors involved in the development of disease. In short, my position is that our DNA is not the key to glaucoma.

The standard party line goes about like the paragraph below, which is written by the distinguished Wallace L.M. Alward, M.D. I do not mean any disrepect to Dr. Alward, but I do wish to highlight that this line of thinking is quickly becoming outdated. Here is what Dr. Alward said in the September 2005 issue of Gleams: 

Glaucoma and genetics: Is DNA the Key?

Submitted by dave on Wed, 02/13/2008 - 12:43am

 

Obviously, genetics are an important factor in how we develop and age. However, genetics are probably one of the most over rated-factors involved in the development of disease. In short, my position is that our DNA is not the key to glaucoma.

The standard party line goes about like the paragraph below, which is written by the distinguished Wallace L.M. Alward, M.D. I do not mean any disrepect to Dr. Alward, but I do wish to highlight that this line of thinking is quickly becoming outdated. Here is what Dr. Alward said in the September 2005 issue of Gleams: 

Subscribe to FitEyes.com RSS Feed Subscribe to genetics